Understanding Adult Acne: A Functional Medicine Perspective
- Bella Dorey
- May 18
- 4 min read
Updated: 1d
Hormonal Changes and Understanding Adult Acne
Hormones play a central role in acne development at any age. In your 30s, hormonal fluctuations can become more pronounced due to several reasons:
Perimenopause and menstrual cycle changes: Even before menopause, hormone levels such as oestrogen and progesterone can fluctuate unpredictably. These changes can increase oil production in the skin, leading to clogged pores and breakouts.
Androgens and DHEA: Androgens, including testosterone and DHEA, stimulate sebaceous glands to produce more sebum. Elevated androgen levels or increased skin sensitivity to these hormones can worsen acne.
Stress hormones: Cortisol, the stress hormone, can indirectly affect hormone balance and inflammation, contributing to acne flare-ups.
Insulin: Diets with a high glycaemic load can contribute to insulin resistance, leading to higher levels of circulating glucose in the blood, which can contribute towards inflammation, worsening acne.
Research shows that adult women with acne often have subtle hormonal imbalances that differ from teenage acne patterns. Functional medicine practitioners focus on identifying these imbalances through detailed hormone testing and personalised treatment plans.
Gut Microbiome Shifts Affecting Skin Health
The gut-skin connection is a growing area of interest in understanding acne. The gut microbiome, the community of bacteria and other microorganisms in the digestive tract, influences inflammation and immune responses throughout the body, including the skin.
Dysbiosis: An imbalance in gut bacteria has been associated with inflammatory skin conditions, including acne. Dysbiosis also interferes with the natural production of anti-inflammatory compounds, like short-chain fatty acids.
Leaky Gut: Otherwise known as 'intestinal permeability', allows toxins and inflammatory molecules to enter the bloodstream, triggering skin inflammation and acne.
Diet: Diets high in sugar, dairy, and processed foods have been linked to acne severity.
Poor digestion: Poor digestion, often caused by stress, dehydration, nutrient deficiencies, or simply not chewing well, can worsen gut health, leading to systemic inflammation.
Studies indicate that improving gut microbiome balance can reduce acne severity, making gut health a key focus in functional medicine approaches.
Stress and Its Impact on Acne
Stress is a common trigger for worsening acne in adults. Chronic stress affects the body in multiple ways that can aggravate skin problems:
Increased cortisol: High cortisol levels promote inflammation and oil production, creating an environment favourable for acne.
Immune system disruption: Stress can weaken immune defences, making it harder for the body to fight off acne-causing bacteria.
Behavioural factors: Stress often leads to poor sleep, unhealthy eating, and neglect of skincare, all of which contribute to acne.
Managing stress through mindfulness, exercise, adequate sleep, and relaxation techniques is essential for controlling adult acne.
Lifestyle Factors That Influence Acne in Your 30s
Several lifestyle habits can worsen acne or hinder its improvement:
Diet: Consuming high-glycaemic foods, dairy, and processed snacks can spike insulin and inflammation, worsening acne.
Skincare products: Using harsh or comedogenic products can irritate the skin and clog pores.
Environmental exposure: Pollution and toxins can increase oxidative stress on the skin.
Liver health: The liver detoxifies hormones and toxins. Poor liver function can lead to hormone imbalances and increased inflammation, affecting skin health.
Functional medicine emphasises a holistic approach, encouraging balanced nutrition, gentle skincare, toxin reduction, and liver support to improve acne outcomes.

Supporting Liver Health for Clearer Skin
The liver plays a vital role in breaking down excess hormones and clearing toxins from the body. When liver function is compromised, hormone imbalances and inflammation can worsen acne.
Detoxification pathways: The liver uses enzymes to process and eliminate hormones like oestrogen and androgens. Supporting these pathways with nutrients such as B vitamins, antioxidants, and glutathione precursors can improve hormone balance.
Avoiding liver stressors: Excess alcohol, processed foods, and environmental toxins can burden the liver, reducing its ability to detoxify effectively.
Functional testing: Some functional medicine practitioners use liver function tests and detox profiles to tailor interventions.
Improving liver health supports overall hormonal balance and reduces systemic inflammation, which can help clear acne.
Practical Steps to Manage Acne in Your 30s
Here are actionable tips based on the functional medicine approach:
Get hormone testing: Identify imbalances in oestrogen, progesterone, testosterone, and cortisol to guide treatment.
Improve gut health: Incorporate prebiotics and an anti-inflammatory diet rich in fibre, omega-3 fats, and antioxidants.
Manage stress: Practice mindfulness, yoga, or other relaxation techniques regularly.
Support liver function: Eat liver-friendly foods like leafy greens, beets, and cruciferous vegetables. Avoid alcohol and processed foods.
Choose gentle skincare: Use non-comedogenic, fragrance-free products suited for sensitive skin that support the skin barrier. Avoid exfoliating acids if the skin barrier is damaged or inflamed.
Stay hydrated and sleep well: Both hydration and quality sleep support skin repair and hormone regulation.
These steps can reduce acne severity and improve skin health over time.
Conclusion: Embracing a Holistic Approach to Skin Health
Acne worsening in your 30s is often a sign of deeper imbalances involving hormones, gut health, stress, and lifestyle factors. Addressing these areas with a functional medicine approach offers a comprehensive way to understand and manage adult acne. If you are struggling with persistent breakouts, consider consulting a specialist who can provide personalised testing and treatment plans tailored to your unique needs. You can find out how to work with me here.
Remember, you are not alone in this journey. With the right support and strategies, clearer skin is within reach.
Bella Dorey is a BANT-registered nutritional therapist and qualified Lifecode GX nutrigenomics practitioner, offering stool, blood and DUTCH hormone testing as part of personalised nutrition programmes. Based in Bury St Edmunds, available online across the UK. Book a free 20-minute discovery call to find out whether hormone testing is right for you.




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